Cell and gene therapy scale-up

At Sagentia, we are highly experienced in developing automated, commercial and large-scale manufacturing processes applicable to cell and gene therapies. Our scientists work at the leading edges of biology, fluidics, engineering and process control to offer:-

• Scale-up: complex system design and development
• In-line sensing:  Cell identification, expression, and expansion diagnostics including apheresis and TCR proteins
• Traditional and advanced sensing techniques: Imaging, optical biosensors, flow cytometry, quartz crystal microbalance
• Smart automation for high-throughput commercial applications
• Electromechanical integration
• ISO and IEC regulatory compliance and Good Manufacturing Practice (GMP)
• Microfluidics

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Sagentia’s work in automated manufacturing systems and scale-up for continuous manufacture includes:-

• Taking novel lab-scale manufacturing processes to scale-up to full GMP pilot lines for use in clinical trials
• Deciphering complex physics issues which were preventing scale up to a production device and delivering a process to manufacturing tolerances
• Scale-up of microfluidic processes for drug production
• Redesign, simplification and production cost reduction
• Function enhancement via use of microfluidic geometries

Complete our contact form for an informal chat with one of our medical technology consultants.